Anthocyanins from Vitis coignetiae Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cellsopen access
- Authors
- Lu, Jing Nan; Lee, Won Sup; Yun, JeongWon; Kim, Min Jeong; Kim, Hye Jung; Kim, Dong Chul; Jeong, Jae-Hoon; Choi, Yung Hyun; Kim, Gon-Sup; Ryu, Chung Ho; Shin, Sung Chul
- Issue Date
- 2013
- Publisher
- HINDAWI LTD
- Citation
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, v.2013
- Indexed
- SCIE
SCOPUS
- Journal Title
- EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
- Volume
- 2013
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/21795
- DOI
- 10.1155/2013/503043
- ISSN
- 1741-427X
- Abstract
- Recently we have demonstrated that anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs) have anticancer effects. Here, we investigate the effects of AIMs on cell proliferation and invasion as well as epithelial-mesenchymal transition (EMT) which have been linked to cancer metastasis in human uterine cervical cancer HeLa cells. AIMs inhibited the invasion of HeLa cells in a dose-dependent manner. AIMs inhibited MMP-9 expression in a dose-dependent manner. AIMs inhibited the motility of HeLa cells in a wound healing test. AIMs still suppressed NF-kappa B activation induced by TNF. AIMs also inhibited EMT in HeLa cells. AIMs suppressed vimentin, N-cadherin, and beta-catenin expression and induced E-cadherin. AIMs also suppressed expression of beta-catenin and Snail, which was regulated by GSK-3. These effects of AIMs were also limited in the HeLa cells treated with TNF. In conclusion, this study indicates that AIMs have anticancer effects by suppressing NF-kappa B-regulated genes and EMT, which relates to suppression of I kappa B alpha. phosphorylation and GSK-3 activity, respectively. However, the effects of AIMs were attenuated in the TNF-high condition.
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- Appears in
Collections - 농업생명과학대학 > 식품공학부 > Journal Articles
- 수의과대학 > Department of Veterinary Medicine > Journal Articles
- College of Medicine > Department of Medicine > Journal Articles
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