Intraovarian transplantation of primordial follicles fails to rescue chemotherapy injured ovariesopen access
- Authors
- Park, Mi-Ryung; Choi, Yun-Jung; Kwon, Deug-Nam; Park, Chankyu; Bui, Hong-Thuy; Gurunathan, Sangiliyandi; Cho, Ssang-Goo; Song, Hyuk; Seo, Han Geuk; Min, Gyesik; Kim, Jin-Hoi
- Issue Date
- 6-Mar-2013
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.3
- Indexed
- SCIE
SCOPUS
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 3
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/20755
- DOI
- 10.1038/srep01384
- ISSN
- 2045-2322
- Abstract
- Busulfan and cyclophosphamide (B/C)-treated mice exhibited a marked increase in apoptosis and a concomitant decrease in the ovarian weight. Histological and RT-PCR analysis indicate that the period of germ cell depletion in the B/C-treated ovaries coincides with decreased expression of genes Figla, Lhx8, Nobox, c-kit, and Sox3. However, depletion of the ovarian germ cells is mediated by autophagy-independent pathways that involve Fas/FasL-, TNF-, and/or p53-signalings. Treatment with B/C resulted in the cease of the reproductive function to produce their offspring during the 15th week post-treatment period in female mice. Furthermore, injection of the 3x10(6) GFP positive primordial follicles into the ovaries of the B/C treatedmouse did not show apparent colonization of the transplanted follicles within the recipient ovaries. The present results suggest that B/C treatment is closely associated with an increased risk of premature ovarian failure.
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