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The Possibility of TBC1D21 as a Candidate Gene for Teat Numbers in Pigsopen access
- Authors
- Jin, S.; Lee, J. B.; Kang, K.; Yoo, C. K.; Kim, B. M.; Park, H. B.; Lim, H. T.; Cho, I. C.; Maharani, D.; Lee, J. H.
- Issue Date
- Oct-2013
- Publisher
- ASIAN-AUSTRALASIAN ASSOC ANIMAL PRODUCTION SOC
- Keywords
- QTL; SNP; SSC7; TBC1D21; Teat Number; Pig
- Citation
- ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, v.26, no.10, pp 1374 - 1378
- Pages
- 5
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
- Volume
- 26
- Number
- 10
- Start Page
- 1374
- End Page
- 1378
- ISSN
- 1011-2367
1976-5517
- Abstract
- Based on a quantitative traits locus (QTL) study using a F-2 intercross between Landrace and Korean native pigs, a significant QTL affecting teat numbers in SSC7 was identified. The strong positional candidate gene, TBC1D21, was selected due to its biological function for epithelial mesenchymal cell development. Sequence analysis revealed six single nucleotide polymorphisms (SNPs) in the TBC1D21 gene. Among these, two SNP markers, one silent mutation (SNP01) for g.13,050A>G and one missense mutation (SNP04) for c.829A>T (S277C), were genotyped and they showed significant associations with teat number traits (p value = 6.38E-05 for SNP01 and p value = 1.06E-07 for SNP04 with total teat numbers). Further functional validation of these SNPs could give valuable information for understanding the teat number variation in pigs.
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