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Proteomic analysis of cloned porcine conceptuses during the implantation period
- Authors
- Ko, Yeoung-Gyu; Park, Hae-Geum; Yeom, Gyu-Tae; Hwang, Seongsoo; Kim, Hyun; Park, Soo-Bong; Yang, Bo-Suck; Song, Young Min; Cho, Jae-Hyeon
- Issue Date
- Dec-2013
- Publisher
- SPRINGER
- Keywords
- Apoptosis-related genes; Birthrate in GM pigs; Conceptuses; Embryo implantation; Gestation day 14; GM-pigs; Proteomic analysis in GM-piglet cells; Somatic cell nuclear transfer
- Citation
- BIOTECHNOLOGY LETTERS, v.35, no.12, pp 2021 - 2030
- Pages
- 10
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOTECHNOLOGY LETTERS
- Volume
- 35
- Number
- 12
- Start Page
- 2021
- End Page
- 2030
- ISSN
- 0141-5492
1573-6776
- Abstract
- Differentially regulated proteins within porcine somatic cell nuclear transfer (SCNT)-derived conceptuses were compared with conceptuses that were derived from natural matings on day 14 of pregnancy. Proteins that were expressed prominently on day 14 were identified in SCNT-derived conceptuses using 2-D PAGE and MALDI-TOF MS. Sixty eight proteins were identified as being differentially regulated in the SCNT-derived conceptuses. Among these, 62 were down-regulated whereas the other six proteins were up-regulated. Glycolytic proteins, such as pyruvate dehydrogenase, malate dehydrogenase and lactate dehydrogenase, were down-regulated in the SCNT-derived conceptuses whereas apoptosis-related genes as annexin V, Hsp60, and lamin A were up-regulated. Thus, apoptosis-related genes are expressed at significantly higher levels in the SCNT-derived conceptuses than in the control conceptuses, whereas metabolism-related genes are significantly reduced.
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