Therapeutic effects of combination of Galla rhois extract and Sodium chlorate on Mice infected with Brucella abortusTherapeutic effects of combination of Galla rhois extract and Sodium chlorate on Mice infected with Brucella abortus
- Other Titles
- Therapeutic effects of combination of Galla rhois extract and Sodium chlorate on Mice infected with Brucella abortus
- Chun-Nam Cha; 홍일화; 유은아; 박은기; 유창열; 김석; 이후장
- Issue Date
- 충북대학교 동물의학연구소
- Brucella abortus; Galla rhois; sodium chlorate; combination; mice
- Journal of Biomedical and Translational Research, v.15, no.1, pp.1 - 6
- Journal Title
- Journal of Biomedical and Translational Research
- Start Page
- End Page
- This study investigated the therapeutic effects of Galla rhois (GR) ethanol extract (GRE), sodium chlorate (SC), and a combination of GRE and SC on mice infected with Brucella abortus (B. abortus). Mice were infected intraperi- toneally with B. abortus and then treated with GRE, SC, and a combination GRE and SC in drinking water for 14 days. Then, serum antibodies were used in a tube aggluti- nation test (TAT), after which the weight and CFUs from each spleen were measured. In addition, histopathologi- cal changes in each liver were examined at 14 days post- infection. At 14 days post-infection, negative reactions of serum antibodies in PC (positive control), SCT (SC 1.6 g/L drinking water), GRT (GRE 200 mg/L drinking water), and GST (GRE 200 mg + SC 1.6 g/L drinking water) were 0, 40, 60, and 80%, respectively. The average spleen weight was not significantly different between the groups. At 14 days post-infection, bacterial numbers in all treated groups were significantly lower compared to to that of the PC (GRT and SCT, P<0.05; GST, P<0.001). In terms of histopathological changes in the livers, there were numerous multifocal mi- crogranulomas in the PC, whereas this number successively decreased in the SCT, GRT, and GST groups. Conclusively, a combination of GRE and SC exhibits therapeutic effects on mice infected with B. abortus. These results suggest the potential efficacy of a mixture of GRE and SC in the treat- ment of brucellosis.
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- 수의과대학 > Department of Veterinary Medicine > Journal Articles
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