Korean Scutellaria baicalensis Georgi methanol extracts inhibits metastasis via the Forkhead Box M1 activity in hepatocellular carcinoma cells
- Authors
- Park, Hyeon Soo; Park, Kwang Il; Hong, Gyeong Eun; Nagappan, Arulkumar; Lee, Ho Jeong; Kim, Eun Hee; Lee, Won Sup; Shin, Sung Chul; Seo, On Nuri; Won, Chung Kil; Cho, Jae Hyeon; Kim, GonSup
- Issue Date
- 8-Aug-2014
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Korean Scutellaria Baicalensis Georgi; Flavonoids; Human hepatocellular carcinoma; Anti-metastasis; Forkhead Box M1 (FOXM1)
- Citation
- JOURNAL OF ETHNOPHARMACOLOGY, v.155, no.1, pp.847 - 851
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF ETHNOPHARMACOLOGY
- Volume
- 155
- Number
- 1
- Start Page
- 847
- End Page
- 851
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/18836
- DOI
- 10.1016/j.jep.2014.05.053
- ISSN
- 0378-8741
- Abstract
- Ethnopharmacological relevance: Scutellaria baicalensis Georgi, commonly known as skullcaps, and it has been widely used as traditional therapeutic herb in several eastern Asia including Korea, China and Japan because of its remarkable anti-inflammatory and anti-cancer effects. Our study focuses on the anti-metastatic effects of Scutellaria baicalensis Georgi in hepatocellular carcinoma (HCC). Materials and methods: Methanol extract of Scutellaria baicalensis Georgi was examined for identification of its composition by HPLC-MS/MS. The extract was evaluated for the anti-metastasis activity using HepG2 hepatocellular carcinoma cells via immunoblotting and RT-PCR. For mechanical study, specific Forkhead Box M1 (FOXM1) vector was transfected to HepG2 cells. Results: Scutellaria baicalensis Georgi potentially inhibited proliferation of HepG2 cells dose dependently. Scutellaria baicalensis Georgi decreased metastasis through the regulation of matrix metalloproteinase 2 (MMP-2) and FOXM1 activities at the transcription and translation levels. Conclusions: The results of the present study suggest that Scutellaria baicalensis Georgi could be a potent chemotherapeutic agent against HCC. Its clinical use guarantee for further study and individual flavonoids from Scutellaria baicalensis Georgi should also be investigated. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
- College of Medicine > Department of Medicine > Journal Articles
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