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Application of Response Surface Methodology to Optimize the Extraction of Acetylcholinesterase Inhibitors from Rhodiola sachalinensis
- Authors
- Kim, Cho Rong; Kim, Jae Kyeom; Shin, Eui-Cheol; Choi, Soo Jung; Kwon, Yoon Kyung; Kim, Youn-Jung; Kim, Chang-Ju; Park, Gwi Gun; Park, Cheung-Seog; Shin, Dong-Hoon
- Issue Date
- Dec-2014
- Publisher
- KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
- Keywords
- acetylcholinesterase; Alzheimer' s disease; response surface methodology; Rhodiola sachalinensis; roseroot
- Citation
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.57, no.6, pp.807 - 811
- Indexed
- SCIE
SCOPUS
KCI
- Volume
- 57
- Number
- 6
- Start Page
- 807
- End Page
- 811
- ISSN
- 1738-2203
- Abstract
- Response surface methodology (RSM) was utilized to optimize extraction conditions for the acetylcholinesterase inhibitor from Rhodiola sachalinensis. Optimized values for AChE inhibition and extraction yield were 19.41 and 13.35%, respectively, and these were in good agreement with the experimental values from validation, suggesting that RSM is a useful tool.
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