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Cited 2 time in webofscience Cited 2 time in scopus
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Impact of DBP on all-cause and cardiovascular mortality: results from the National Health and Nutrition Examination survey, 1999-2014

Authors
Bae, EunjinRocco, Michael V.Lee, JeonghwanPark, Jae YoonKim, Yong ChulYoo, Kyung DonKim, Eun YoungPark, Dong JunLim, Chun SooKim, Yon SuLee, Jung Pyo
Issue Date
Jan-2022
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Keywords
diastolic blood pressure; isolated diastolic hypertension; mortality
Citation
JOURNAL OF HYPERTENSION, v.40, no.1, pp.108 - 116
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF HYPERTENSION
Volume
40
Number
1
Start Page
108
End Page
116
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/1807
DOI
10.1097/HJH.0000000000002983
ISSN
0263-6352
Abstract
Introduction: Hypertension is common and has a significant effect on cardiovascular morbidity and death. However, despite the development of several guidelines to manage SBP, there is little research or guidance on the evaluation and management of DBP or isolated diastolic hypertension (IDH). Method: To determine the association of DBP with all-cause and cardiovascular mortality, we used NHANES data from 1999 to 2014 and included adults aged at least 18 years. The relationship between DBP, IDH and all-cause, cardiovascular mortality was evaluated. Results: Of the 35 109 participants, all-cause death occurred in 10.6%, and cardiovascular death occurred in 2.1% over a median follow-up of 7.2 years. Multivariate Cox regression analysis revealed that the risk of all-cause mortality was significantly higher in the lowest (<= 56.9 mmHg) DBP groups than in the reference group (DBP 74-76.9 mmHg). However, the risk of cardiovascular mortality was significantly higher in the lowest and highest (>= 83 mmHg) DBP group than in the reference group. The risk of all-cause mortality was higher for most groups with SBP at least 140 mmHg than for the reference group with DBP 74-76.9 mmHg and SBP 100-139.9 mmHg. Both the 2018 ESC/NICE and the 2017 AHA/ACC-defined IDH was not significantly associated with all-cause mortality. Conclusion: DBP and all-cause mortality had an inverse relationship, whereas DBP and cardiovascular mortality had a U-shaped relationship, with the DBP reference group having the lowest risk for all-cause and cardiovascular mortality. There was no significant relationship between IDH and death.
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