The two highly immunogenic antigens of Brucella: lipopolysaccharide (LPS) and outer membrane proteins (OMPs)The two highly immunogenic antigens of Brucella: lipopolysaccharide (LPS) and outer membrane proteins (OMPs)
- Other Titles
- The two highly immunogenic antigens of Brucella: lipopolysaccharide (LPS) and outer membrane proteins (OMPs)
- Authors
- REYESALISHA WEHDNESDAY; Hannah Leah Tadeja Simborio; Huynh Tan Hop; Lauren Togonon Arayan; Tran Xuan Ngoc Huy; 민원기; 김석
- Issue Date
- 2015
- Publisher
- 한국예방수의학회
- Keywords
- Brucella abortus; lipopolysaccharide; outer membrane proteins; virulence
- Citation
- 예방수의학회지, v.39, no.4, pp.198 - 206
- Indexed
- KCI
- Journal Title
- 예방수의학회지
- Volume
- 39
- Number
- 4
- Start Page
- 198
- End Page
- 206
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/17792
- DOI
- 10.13041/jpvm.2015.39.4.198
- ISSN
- 2287-7991
- Abstract
- The bacterial lipopolysaccharide (LPS) mainly contributes to the structural integrity, survival and protection barrier against harsh environments. Therefore, the early stages in LPS or lipid A biosynthesis are attractive targets in the identification and development of inhibitors which would be effective against infections caused by Gram-negative bacteria. The bacterial outer membrane proteins (OMPs) meanwhile function as maintenance for structure, adhesion to other cells and substances, as well as development of resistance to antimicrobials. The LPS and LPS-related molecules, and OMPs are important immunogenic components of several important pathogens including Brucella, which have been extensively used in immunological studies and in the diagnosis of diseases. Here we review the importance, structure, functions and immunogenic aspects of LPS and OMPs particularly of Brucella which can be targeted for the prevention and diagnosis of brucellosis.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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