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Cited 9 time in webofscience Cited 10 time in scopus
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In situ x-ray-induced acoustic computed tomography with a contrast agent: a proof of concept

Authors
Choi, SeongwookPark, SinyoungPyo, AyoungKim, Dong-YeonMin, Jung-JoonLee, ChanghoKim, Chulhong
Issue Date
1-Jan-2022
Publisher
Optical Society of America
Citation
Optics Letters, v.47, no.1, pp 90 - 93
Pages
4
Indexed
SCIE
SCOPUS
Journal Title
Optics Letters
Volume
47
Number
1
Start Page
90
End Page
93
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/1764
DOI
10.1364/OL.447618
ISSN
0146-9592
1539-4794
Abstract
X-ray-induced acoustic computed tomography (XACT) has shown great potential as a hybrid imaging modality for real-time non-invasive x-ray dosimetry and low-dose three-dimensional (3D) imaging. While promising, one drawback of the XACT system is the underlying low signal-to-noise ratio (SNR), limiting its in vivo clinical use. In this Letter, we propose the first use of a conventional x-ray computed tomography contrast agent, Gastrografin, for improving the SNR of in situ XACT imaging. We obtained 3D volumetric XACT images of a mouse's stomach with orally injected Gastrografin establishing the proposal's feasibility. Thus, we believe, in the future, our proposed technique will allow in vivo imaging and expand or complement conventional x-ray modalities, such as radiotherapy and accelerators. (C) 2021 Optica Publishing Group
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