In situ x-ray-induced acoustic computed tomography with a contrast agent: a proof of concept
- Choi, Seongwook; Park, Sinyoung; Pyo, Ayoung; Kim, Dong-Yeon; Min, Jung-Joon; Lee, Changho; Kim, Chulhong
- Issue Date
- OPTICAL SOC AMER
- OPTICS LETTERS, v.47, no.1, pp.90 - 93
- Journal Title
- OPTICS LETTERS
- Start Page
- End Page
- X-ray-induced acoustic computed tomography (XACT) has shown great potential as a hybrid imaging modality for real-time non-invasive x-ray dosimetry and low-dose three-dimensional (3D) imaging. While promising, one drawback of the XACT system is the underlying low signal-to-noise ratio (SNR), limiting its in vivo clinical use. In this Letter, we propose the first use of a conventional x-ray computed tomography contrast agent, Gastrografin, for improving the SNR of in situ XACT imaging. We obtained 3D volumetric XACT images of a mouse's stomach with orally injected Gastrografin establishing the proposal's feasibility. Thus, we believe, in the future, our proposed technique will allow in vivo imaging and expand or complement conventional x-ray modalities, such as radiotherapy and accelerators. (C) 2021 Optica Publishing Group
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- 약학대학 > 약학과 > Journal Articles
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