The flavonoid morin from Moraceae induces apoptosis by modulation of Bcl-2 family members and Fas receptor in HCT 116 cellsopen access
- Authors
- Hyun, Hwang-Bo; Lee, Won Sup; Go, Se-Il; Nagappan, Arulkumar; Park, Cheol; Han, Min Ho; Hong, Su Hyun; Kim, Gonsup; Kim, Gi Young; Cheong, Jaehun; Ryu, Chung Ho; Shin, Sung Chul; Choi, Yung Hyun
- Issue Date
- Jun-2015
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- morin; Bcl-2; Fas receptor; HCT-116 human colon cancer cells
- Citation
- INTERNATIONAL JOURNAL OF ONCOLOGY, v.46, no.6, pp.2670 - 2678
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF ONCOLOGY
- Volume
- 46
- Number
- 6
- Start Page
- 2670
- End Page
- 2678
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/17206
- DOI
- 10.3892/ijo.2015.2967
- ISSN
- 1019-6439
- Abstract
- It is evident based on literature that flavonoids from fruit can safely modulate cancer cell biology and induce apoptosis. Therefore, we investigated the anticancer activity of morin, a flavonoid which is plentiful in twigs of mulberry focusing on apoptosis, and its mechanisms. Morin upregulated the Fas receptor, and activates caspase-8, -9 and -3 in HCT-116 cells. Morin also activates Bid, and induced the loss of mitochondrial membrane potential (MMP, Delta Psi(m)) with Bax protein activation and cytochrome c release. In addition, morin induced ROS generation which was not blocked by N-acetylcysteine. Morin also suppressed Bcl-2 and cIAP-1, anti-apoptotic proteins, which may contribute to augmentation of morin-triggered apoptosis. As an upstream signaling pathway, suppressed Akt activity by morin was associated to apoptosis. This study suggests that morin induces caspase-dependent apoptosis through extrinsic pathway by upregulating Fas receptor as well as through the intrinsic pathway by modulating Bcl-2 and TAP family members, and ROS generation, and that Akt is the critical upstream signaling that regulates the apoptotic effect of morin in human colon cancer HCT-116 cells.
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Collections - 농업생명과학대학 > 식품공학부 > Journal Articles
- 수의과대학 > Department of Veterinary Medicine > Journal Articles
- College of Medicine > Department of Medicine > Journal Articles
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