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Inhibition of Vascular Endothelial Growth Factor Receptor 3 Reduces Migration of Gastric Cancer Cells
- Issue Date
- 14-Sep-2015
- Publisher
- TAYLOR & FRANCIS INC
- Keywords
- Cell movement; Gastric neoplasms; Vascular endothelial growth factor C; Vascular endothelial growth factor receptor-3
- Citation
- CANCER INVESTIGATION, v.33, no.8, pp.398 - 404
- Indexed
- SCIE
SCOPUS
- Journal Title
- CANCER INVESTIGATION
- Volume
- 33
- Number
- 8
- Start Page
- 398
- End Page
- 404
- ISSN
- 0735-7907
- Abstract
- Angiogenesis induced by proangiogenic molecules such as vascular endothelial growth factor (VEGF) is a key process in the progression and metastasis of gastric cancer. In this study, we investigated the role of VEGF-C/VEGF receptor 3 (VEGFR3) axis in cell proliferation and migration/invasion of human gastric cancer cells (hGCCs). VEGF-C did not enhance cell proliferation but increased cell migration/invasion by approximately approximate to 50% in hGCCs (AGS and SNU-484). MAZ51, a VEGFR3 inhibitor, reduced the VEGF-C-induced increase in migration/invasion by approximate to 30% (p < 0.05). These results suggest that VEGFR3 could be a therapeutic target for reducing the metastasis of gastric cancer cells.
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