A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophagesopen access
- Authors
- Won, Kyung-Jong; Park, Sung-Won; Lee, Seunghoon; Kong, Il-Keun; Chae, Jung-Il; Kim, Bokyung; Lee, Eun-Jong; Kim, Dong-Ku
- Issue Date
- Oct-2015
- Publisher
- KOREA ASSOC IMMUNOLOGISTS
- Keywords
- TLT-6; ITIM motif; Anti-proliferation; Macrophages; TREM family
- Citation
- IMMUNE NETWORK, v.15, no.5, pp.232 - 240
- Indexed
- KCI
- Journal Title
- IMMUNE NETWORK
- Volume
- 15
- Number
- 5
- Start Page
- 232
- End Page
- 240
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/16981
- DOI
- 10.4110/in.2015.15.5.232
- ISSN
- 1598-2629
- Abstract
- The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study, we aimed to identify a novel receptor expressed on hematopoietic stem cells (HSCs) by using in silico bioinformatics and to characterize the identified receptor. We thus found the TREM-like transcript (TLT)-6, a new member of TREM family. TLT-6 has a single immunoglobulin domain in the extracellular region and a long cytoplasmic region containing 2 immunoreceptor tyrosine-based inhibitory motif-like domains. TLT-6 transcript was expressed in HSCs, monocytes and macrophages. TLT-6 protein was up-regulated on the surface of bone marrow-derived and peritoneal macrophages by lipopolysaccharide stimulation. TLT-6 exerted anti-proliferative effects in macrophages. Our results demonstrate that TLT-6 may regulate the activation and proliferation of macrophages.
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