Temporal Evolution of MRI Characteristics in Dogs with Collagenase-Induced Intracerebral Hemorrhage
- Authors
- An, Daegi; Park, Junyong; Shin, Jong-Il; Kim, Hyung-Joong; Jung, Dong-In; Kang, Ji-Houn; Kim, Gonhyung; Chang, Dong-Woo; Sur, Jung-Hyang; Yang, Mhan-Pyo; Lee, Chulhyun; Kang, Byeong-Teck
- Issue Date
- Dec-2015
- Publisher
- AMER ASSOC LABORATORY ANIMAL SCIENCE
- Keywords
- ADC; Apparent diffusion coefficient; DWI; Diffusion-weighted imaging; FLAIR; Fluid attenuation inversion recovery; GRE; Gradient echo; ICH; Intracerebral hemorrhage; ROI; Region of interest; SIR; Signal intensity ratio; WI; Weighted imaging
- Citation
- COMPARATIVE MEDICINE, v.65, no.6, pp.517 - 525
- Indexed
- SCIE
SCOPUS
- Journal Title
- COMPARATIVE MEDICINE
- Volume
- 65
- Number
- 6
- Start Page
- 517
- End Page
- 525
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/16873
- ISSN
- 1532-0820
- Abstract
- Intracerebral hemorrhage (ICH) is one of the most lethal types of stroke. Neuroimaging techniques, particularly MRI, have improved the diagnostic accuracy of ICH. The MRI characteristics of the evolving stages of ICH in humans-but not those in dogs-have been described. In this study, we document the temporal MRI characteristics in a canine model of collagenase-induced ICH. Specifically, ICH was induced in 5 healthy beagles by injecting 500 U of bacterial collagenase from Clostridium histolyticum, which was delivered into the parietal lobe over 5 min by using a microinfusion pump. T1- and T2-weighted, fluid-attenuated inversion recovery, gradient-echo (GRE), and diffusion-weighted (DWI) imaging and measurement of the apparent diffusion coefficient (ADC) were performed serially at 6 different time points (before and 12 h, 3 d, 5 d, 10 d and 24 d after hemorrhage) by using a 3-T MR system. The temporal changes of T1 signal intensity (SI) corresponded well with the reported human data. The temporal changes of T2 and GRE sequences, with the exception of T2 and GRE hyperintensities at the early subacute stage, also matched. ADC measurements were high at the early subacute stage, and DWI-SI positively correlated with T2- and GRE-SI from the early subacute stage onward. In conclusion, MRI is an ideal method for characterizing the temporal evolution of parenchymal alterations after ICH in dogs. These data might be useful for differentiating clinical stages of ICH in dogs.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.gnu.ac.kr/handle/sw.gnu/16873)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.