Detailed Information

Cited 1 time in webofscience Cited 1 time in scopus
Metadata Downloads

Prognostic Value of NOX4 Expression in Cancer Patients: A Systematic Review and Meta-analysisopen access

Authors
Koh, Hyun MinJang, Bo GunHyun, Chang LimKim, Dong Chul
Issue Date
28-Feb-2022
Publisher
IOS Press
Citation
Disease Markers, v.2022
Indexed
SCIE
SCOPUS
Journal Title
Disease Markers
Volume
2022
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/1594
DOI
10.1155/2022/8567642
ISSN
0278-0240
1875-8630
Abstract
Background. Recent studies have shown that nicotinamide adenosine dinucleotide phosphate oxidase 4 (NOX4) is related to cancer development, proliferation, invasion, epithelial-to-mesenchymal transition, and metastasis. The prognostic value of NOX4 expression although has been reported in various cancers, it remains unclear as several studies have reported conflicting results. Therefore, the purpose of this study was to systematically investigate the prognostic value of NOX4 expression in cancer patients. Method. Appropriate studies were collected by searching the PubMed, EMBASE, and Cochrane library databases, and the prognostic value of NOX4 expression in cancer patients was assessed through a meta-analysis. Results. Nine eligible studies involving 2675 cancer patients were included in this meta-analysis. We found that NOX4 expression is related to prognosis in cancer patients. In particular, high expression of NOX4 was significantly associated with overall survival in patients with gastrointestinal cancer (hazard ratio [HR]: 1.83, 95% confidence interval [CI]: 1.39-2.42, p < 0.001). Conclusion. NOX4 expression is significantly correlated with overall survival in patients with gastrointestinal cancer, indicating that it could be a potential prognostic marker.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Dong Chul photo

Kim, Dong Chul
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE