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Cited 2 time in webofscience Cited 3 time in scopus
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Cyclin D1 Serves as a Poor Prognostic Biomarker in Stage I Gastric Canceropen access

Authors
Go, Se-IlKo, Gyung HyuckLee, Won SupLee, Jeong-HeeJeong, Sang-HoLee, Young-JoonHong, Soon ChanHa, Woo Song
Issue Date
Mar-2022
Publisher
MDPI
Keywords
cyclin D1; epidermal growth factor receptor (EGFR); stage I gastric cancer; early gastric cancer; node-negative gastric cancer
Citation
CURRENT ISSUES IN MOLECULAR BIOLOGY, v.44, no.3, pp.1395 - 1406
Indexed
SCIE
SCOPUS
Journal Title
CURRENT ISSUES IN MOLECULAR BIOLOGY
Volume
44
Number
3
Start Page
1395
End Page
1406
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/1590
DOI
10.3390/cimb44030093
ISSN
1467-3037
Abstract
TNM stage still serves as the best prognostic marker in gastric cancer (GC). The next step is to find prognostic biomarkers that detect subgroups with different prognoses in the same TNM stage. In this study, the expression levels of epidermal growth factor receptor (EGFR) and cyclin D1 were assessed in 96 tissue samples, including non-tumorous tissue, adenoma, and carcinoma. Then, the prognostic impact of EGFR and cyclin D1 was retrospectively investigated in 316 patients who underwent R0 resection for GC. EGFR positivity increased as gastric tissue became malignant, and cyclin D1 positivity was increased in all the tumorous tissues. However, there was no survival difference caused by the EGFR positivity, while the cyclin D1-postive group had worse overall survival (OS) than the cyclin D1-negative group in stage I GC (10-year survival rate (10-YSR): 62.8% vs. 86.5%, p = 0.010). In subgroup analyses for the propensity score-matched (PSM) cohort, there were also significant differences in the OS according to the cyclin D1 positivity in stage I GC but not in stage II and III GC. Upon multivariate analysis, cyclin D1 positivity was an independent prognostic factor in stage I GC. In conclusion, cyclin D1 may be a useful biomarker for predicting prognosis in stage I GC.
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