Lower Extremity Arterial Calcification as a Predictor of Coronary Atherosclerosis in Patients with Peripheral Arterial Diseaseopen access
- Authors
- Shin, Hwa Seon; Park, Mi Jung; Jeon, Kyung Nyeo; Cho, Jae Min; Bae, Kyung Soo; Choi, Dae Seob; Na, Jae Boem; Choi, Ho Cheol; Choi, Hye Young; Kim, Ji Eun; Cho, Soo Bueum; Park, Sung Eun
- Issue Date
- Apr-2016
- Publisher
- KOWSAR PUBL
- Keywords
- Atherosclerosis; Coronary Artery Disease; Multidetector Computed Tomography; Peripheral Arterial Disease; Vascular Calcification
- Citation
- IRANIAN JOURNAL OF RADIOLOGY, v.13, no.2
- Indexed
- SCIE
SCOPUS
- Journal Title
- IRANIAN JOURNAL OF RADIOLOGY
- Volume
- 13
- Number
- 2
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/15593
- DOI
- 10.5812/iranjradiol.33179
- ISSN
- 1735-1065
- Abstract
- Background: Until now, there has been no study on the relationship between the calcification of the lower extremity arteries and significant coronary arterial disease (CAD). Objectives: To evaluate whether lower extremity calcium scores (LECS) are associated with CAD and whether this can predict multivessel-CAD in patients with peripheral arterial disease (PAD). Patients and Methods: We retrospectively enrolled 103 PAD patients without cardiac symptoms or known CAD. All patients underwent cardiac computed tomography (CT) and lower extremity CT within 1 month and were categorized as nonsignificant CAD, single-CAD, or multivessel-CAD. The coronary calcium scores (CCS) were quantitatively measured according to the Agatston method and LECS were semi-quantitatively measured according to the presence of lower extremity calcification in the segment. The extent of CAD was evaluated according to the presence of >= 50% luminal diameter stenosis in the segment of CAD. Results: LECS in multivessel-CAD were significantly higher than those in nonsignificant CAD (10.0 +/- 5.8 versus 4.0 +/- 3.1, P < 0.001). LECS significantly correlated with CCS (r = 0.831, P < 0.001) and the extent of CAD (r = 0.631, P < 0.001). Multivariate regression analysis demonstrated LECS and log-transformed CCS were independent predictors for multivessel-CAD. In receiver operating characteristic curve analysis, the diagnostic performance of LECS was 0.807 (95% confidence interval = 0.724-0.891, P < 0.001) for predicting multivessel-CAD. Conclusion: Peripheral arterial calcification is significantly correlated with CAD extent in patients with PAD. Peripheral arterial calcification can be a useful marker for predicting multivessel-CAD.
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