Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25open access
- Kim, D.; Kim, M.; Kim, T.W.; Choe, Y.-H.; Noh, H.S.; Jeon, H.M.; Kim, H.; Lee, Y.; Hur, G.; Lee, K.-M.; Shin, K.; Lee, S.-I.; Lee, S.-H.
- Issue Date
- Rockefeller University Press
- Journal of Experimental Medicine, v.219, no.5
- Journal Title
- Journal of Experimental Medicine
- Lymph node fibroblastic reticular cells (LN-FRCs) provide functional structure to LNs and play important roles in interactions between T cells and antigen-presenting cells. However, the direct impact of LN-FRCs on naive CD4+ T cell differentiation has not been explored. Here, we show that T cell zone FRCs of LNs (LN-TRCs) express CD25, the α chain of the IL-2 receptor heterotrimer. Moreover, LN-TRCs trans-present IL-2 to naive CD4+ T cells through CD25, thereby facilitating early IL-2?mediated signaling. CD25-deficient LN-TRCs exhibit attenuated STAT5 phosphorylation in naive CD4+ T cells during T cell differentiation, promoting T helper 17 (Th17) cell differentiation and Th17 response-related gene expression. In experimental autoimmune disease models, disease severity was elevated in mice lacking CD25 in LN-TRCs. Therefore, our results suggest that CD25 expression on LN-TRCs regulates CD4+ T cell differentiation by modulating early IL-2 signaling of neighboring, naive CD4+ T cells, influencing the overall properties of immune responses. ? 2022 Kim et al.
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- College of Medicine > Department of Medicine > Journal Articles
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