Vitamin C induces apoptosis in AGS cells via production of ROS of mitochondriaopen access
- Lim, Jae Young; Kim, Donghyun; Kim, Bok Ran; Jun, Jin Su; Yeom, Jung Sook; Park, Ji Sook; Seo, Ji-Hyun; Park, Chan Hoo; Woo, Hyang Ok; Youn, Hee-Shang; Baik, Seung-Chul; Lee, Woo-Kon; Cho, Myung-Je; Rhee, Kwang-Ho
- Issue Date
- SPANDIDOS PUBL LTD
- vitamin C; apoptosis; reactive oxygen species
- ONCOLOGY LETTERS, v.12, no.5, pp.4270 - 4276
- Journal Title
- ONCOLOGY LETTERS
- Start Page
- End Page
- It has been demonstrated that vitamin C exhibits anti-cancer activity in various tumor cell lines; however, its specific mechanism of action remains unknown. Although the diagnosis and therapy of cancer patients have markedly improved in recent years, safer and more cost-effective treatments are still required. Therefore, the present study examined the effect of vitamin C on the induction of cell death in gastric cancer and its underlying mechanism of action. It was observed that the cytotoxicity of vitamin C on the human gastric cancer cell line AGS is dependent on the apoptotic pathway, including caspase cascades, but not on the necroptotic pathway. It was demonstrated that the vitamin C-induced calcium influx and ROS generation have critical roles in the induction of apoptosis. Furthermore, vitamin C treatment depleted adenosine triphosphate (ATP) production in AGS cells, and the autophagy pathway may be involved in this process. Taken together, the current study suggests that a high dose of vitamin C may induce gastric cancer cell apoptosis through the dysfunction of mitochondria, including calcium influx, reactive oxygen species generation and ATP depletion.
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- College of Medicine > Department of Medicine > Journal Articles
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