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Cited 3 time in webofscience Cited 3 time in scopus
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Jageum-Jung, the herbal pharmaceuticals, inhibits the hepatic fibrogenesis as mediated with TGF-beta 1/smad signaling

Authors
Song, Yu RimJang, Mi HeeJang, BoyunBae, Su JinBak, Seon BeenLee, Sung MinYun, Un-JungLee, Ju HeePark, Sang MiJung, Dae HwaSa, Bok SukSong, Jong KukLee, Eun HyeKim, Kwang YounPark, Kwang-IlKim, Young WooKim, Sang Chan
Issue Date
Apr-2022
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Keywords
Herbal pharmaceutical; Jageum-Jung; Liver fibrosis; TGF-beta 1/smad
Citation
MOLECULAR & CELLULAR TOXICOLOGY, v.18, no.2, pp.243 - 251
Indexed
SCIE
SCOPUS
KCI
Journal Title
MOLECULAR & CELLULAR TOXICOLOGY
Volume
18
Number
2
Start Page
243
End Page
251
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/1418
DOI
10.1007/s13273-021-00196-9
ISSN
1738-642X
Abstract
Background Herbal prescriptions have various effects and their efficacy is potentiated by the use of combinations of medicinal herbs. Objective Jageum-Jung (JGJ) is a traditional oriental medical prescription composed of five herbs. It has been used for detoxification, and as an anti-inflammatory and antitumor agent. However, the effect of JGJ on hepatic fibrogenesis is unclear. Results We investigated the role of JGJ in TGF-beta 1/smad signaling, which is implicated in fibrogenesis, and its hepatoprotective effect in CCl4-treated mice with liver fibrosis. Treatment of LX-2 cells with TGF-beta induced expression of mediators (alpha-SMA, PAI-1, and MMP-2) of fibrogenesis and activation of proinflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6). However, these were downregulated by pretreatment with JGJ. In mice, oral administration of JGJ prevented liver injury induced by CCl4, as indicated by decreases in the ALT and AST levels. Conclusions JGJ inhibits hepatic fibrogenesis and TGF-beta 1/Smad signaling.
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