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Cited 11 time in webofscience Cited 13 time in scopus
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The effect of polycyclic aromatic hydrocarbons on changes in the brain structure of firefighters: An analysis using data from the Firefighters Research on Enhancement of Safety & Health study

Authors
Kim, Yun TaeKim, WoojinBae, Mun-JooChoi, Jee EunKim, Mi-JiOh, Sung SooPark, Ki SooPark, SunghaLee, Seung-KooKoh, Sang-BaekKim, Changsoo
Issue Date
10-Apr-2022
Publisher
Elsevier BV
Keywords
Neuroimaging; Brain cortical thickness; Urinary metabolites; Hypertension; Smoking
Citation
Science of the Total Environment, v.816
Indexed
SCIE
SCOPUS
Journal Title
Science of the Total Environment
Volume
816
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/1392
DOI
10.1016/j.scitotenv.2021.151655
ISSN
0048-9697
1879-1026
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are formed during incomplete combustion of organic matter, and firefighters are highly exposed to these toxic compounds at fire sites. Exposure to PAHs can cause cognitive decline and neurodegeneration; however, to date, few studies have examined the potential effects of PAH exposure on structural changes in the brain. We aimed to investigate the association between the four types of PAH metabolites and the corresponding changes in neuroimaging markers based on smoking status and hypertension in male firefighters. For this, we utilized the 2-year follow-up data of 301 Korean male firefighters aged over 40 years. The concentrations of four PAH metabolites in urine were measured. Subcortical volume and cortical thickness were estimated using 3 T magnetic resonance imaging of the brain. A generalized linear model was used to investigate the effects of PAHs on changes in the subcortical volume and cortical thickness. We found an association between 1-hydroxyphenathrene (1-OHPHE) and 2-hydroxyfluorene (2-OHF) and changes in several brain regions in all the study participants. Individuals who had never smoked showed significantly thinner frontal (p < 0.001), parietal (p < 0.001), temporal (p < 0.001), and cingulate lobes (p < 0.001) with 1% increase each in the urinary concentration of 1-OHPHE. Hypertension interacted with the concentration of 1-OHPHE to reduce the volume of gray matter and cause cortical thinning in the frontal, parietal, and temporal lobes. Exposure to PAHs may reduce cortical thickness and subcortical volume, which are definitive markers of neurodegeneration. Notably, hyper-tension can accelerate the degenerative effects of PAHs. (C) 2021 Elsevier B.V. All rights reserved.
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