A chaperone surveillance system in plant circadian rhythmsopen access
- Authors
- Cha, Joon-Yung; Khaleda, Laila; Park, Hee Jin; Kim, Woe-Yeon
- Issue Date
- 31-May-2017
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- Chaperone; Circadian clock; GIGANTEA; HSP90; ZEITLUPE
- Citation
- BMB REPORTS, v.50, no.5, pp.235 - 236
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 50
- Number
- 5
- Start Page
- 235
- End Page
- 236
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/13717
- DOI
- 10.5483/BMBRep.2017.50.5.064
- ISSN
- 1976-6696
- Abstract
- The circadian clock is an internal system that is synchronized by external stimuli, such as light and temperature, and influences various physiological and developmental processes in living organisms. In the model plant Arabidopsis, transcriptional, translational and post-translational processes are interlocked by feedback loops among morning-and evening-phased genes. In a post-translational loop, plant-specific single-gene encoded GIGANTEA (GI) stabilize the F-box protein ZEITLUPE (ZTL), driving the targeted-proteasomal degradation of TIMING OF CAB EXPRESSION 1 (TOC1) and PSEUDO-RESPONSE REGULATOR 5 (PRR5). Inherent to this, we demonstrate the novel biochemical function of GI as a chaperone and/or co-chaperone of Heat-Shock Protein 90 (HSP90). GI prevents ZTL degradation as a chaperone and facilitates ZTL maturation together with HSP90/HSP70, enhancing ZTL activity in vitro and in planta. GI is known to be involved in a wide range of physiology and development as well as abiotic stress responses in plants, but it could also interact with diverse client proteins to increase protein maturation. Our results provide evidence that GI helps proteostasis of ZTL by acting as a chaperone and a co-chaperone of HSP90 for proper functioning of the Arabidopsis circadian clock.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.gnu.ac.kr/handle/sw.gnu/13717)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.