Sensitivity Analysis in 3D Manipulation of Biological Nanoparticles

Abstract

Computer simulations to predict the motion of nanoparticles had been developed for Atomic Force Microscopy (AFM) based robots. The proposed model includes a system of coupled nonlinear equations which determine the system dynamics. As biological nanoparticles are fragile by nature, it is important to apply the exact amount of pressure during manipulation process. Therefore, the sensitivity analysis simulation has been performed to study the effects of inflectional parameters. Using derivative sensitivity analysis, the effects of geometrical (particle and cantilever shapes), process (user defined) and environmental parameters have been investigated and the most influential parameters have been introduced. The simulations provide a real-time platform and make the biological nanoparticles positioning more practical.