Detailed Information
Cited 6 time in 
Cited 6 time in 
Cited 6 time in
Metadata Downloads
The first report of CD2 associated protein gene, in a teleost (Rock bream, Oplegnathus fasciatus): An investigation of the immune response upon infection with several pathogens
- Authors
- Cho, Dong-Hee; Bae, Jin-Sol; Jeong, Ji-Min; Han, Hyun-Ja; Lee, Deok Chan; Cho, Mi Young; Jung, Sung Hee; Kim, Do-Hyung; Park, Chan-Il
- Issue Date
- Aug-2017
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- Rock bream; CD2-Associated protein; T cells; SH3 domain; Gene expression
- Citation
- FISH & SHELLFISH IMMUNOLOGY, v.67, pp 1 - 6
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- FISH & SHELLFISH IMMUNOLOGY
- Volume
- 67
- Start Page
- 1
- End Page
- 6
- ISSN
- 1050-4648
1095-9947
- Abstract
- CD2 is expressed on the surfaces of virtually all T cells and natural killer (NK) cells. In mammals, the CD2 molecule is 50 kDa. The cytoplasmic tail of CD2 interacts with CD2-associated protein (CD2AP), which plays an important role in mediating the trigger signal in outer magnetic pole cells. In this study, we identified CD2AP from rock bream and investigated its gene expression. The ORF of CD2AP (1950 bp) encodes 650 amino acids (aa). CD2AP has a Src homology 3 (SH3) domain. Quantitative real-time PCR analysis revealed that CD2AP shows higher expression in the gills and skin. Under experimental challenge, CD2AP gene expression was increased as relative to the control after 7 days. This result will improve our understanding of blood vessels in teleost fish, and will provide a basis for the study of CD2-related genes. (C) 2017 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 해양과학대학 > ETC > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.