Complete genome sequence of a novel porcine hemagglutinating encephalomyelitis virus strain identified in South Koreaopen access
- Kim, Yeeun; Lee, Kyung Min; Jang, Guehwan; Lee, Changhee
- Issue Date
- SPRINGER WIEN
- ARCHIVES OF VIROLOGY, v.167, no.5, pp.1381 - 1385
- Journal Title
- ARCHIVES OF VIROLOGY
- Start Page
- End Page
- Porcine hemagglutinating encephalomyelitis virus (PHEV) is a member of the subgenus Embecovirus of the genus Betacoronavirus, and it is ubiquitously distributed in most pig-farming countries worldwide with low clinical incidence. Here, we report the full-length genome sequence and molecular characterization of a novel PHEV strain identified in diarrheic neonates in South Korea. The complete genome of the Korean PHEV strain GNU-2113 was sequenced and analyzed to characterize PHEV circulating in South Korea. The GNU-2113 genome was determined to be 29,982 nucleotides in length, with large unique deletions in the regions encoding nonstructural protein 3 and NS2. It was found to share 95.1-96.9% sequence identity with other global strains. Genetic and phylogenetic analysis indicated that the GNU-2113 strain is distantly related to the existing PHEV genotypes, implying that the virus appears to undergo substantial evolution under endemic pressure. This study provides important information about the genetic diversity of PHEV circulating subclinically in swine herds, which may ensure viral fitness in the enzootic environment.
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- 수의과대학 > Department of Veterinary Medicine > Journal Articles
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