Downregulation of inflammatory cytokines by berberine attenuates Riemerella anatipestifer infection in ducks
- Authors
- Fernandez, Cherry P.; Afrin, Fahmida; Flores, Rochelle A.; Kim, Woo H.; Jeong, Jipseol; Kim, Suk; Chang, Hong H.; Lillehoj, Hyun S.; Min, Wongi
- Issue Date
- Dec-2017
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Ducks; Riemerella infection; Berberine; Downregulation of inflammatory cytokines
- Citation
- DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, v.77, pp.121 - 127
- Indexed
- SCIE
SCOPUS
- Journal Title
- DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
- Volume
- 77
- Start Page
- 121
- End Page
- 127
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/13302
- DOI
- 10.1016/j.dci.2017.07.027
- ISSN
- 0145-305X
- Abstract
- Riemerella anatipestifer, an important infectious bacterium affecting the duck industry, has 5-75% mortality, depending on strain virulence. We previously demonstrated that proinflammatory cytokines are involved in inflammation during, and regulating susceptibility to, R. anatipestifer infection. We investigated the effects of the anti-inflammatory compound berberine in duck splenic lymphocytes stimulated with killed R. anatipestifer, and in R. anatipestifer-infected ducks. IL-17A, IL-17F, and IL-1 beta transcripts were downregulated, and IFN-gamma and IL-10 transcripts enhanced, in berberine-treated stimulated splenic lymphocytes, compared to stimulated untreated splenic lymphocytes. Similarly, IL-17A, IL-17F, IL-6, and IL-1 beta expressions were significantly reduced, and IFN-gamma and IL-10 expressions significantly upregulated, in spleens and livers of R. anatipestifer-infected berberine-treated ducks, compared to infected untreated birds. Moreover, infected and treated birds showed increased survival rates and significantly decreased bacterial burdens compared to infected untreated birds, confirming that inflammatory cytokines are strongly associated with R. anatipestifer infection in ducks. (C) 2017 Elsevier Ltd. All rights reserved.
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Collections - 농업생명과학대학 > 축산과학부 > Journal Articles
- 수의과대학 > Department of Veterinary Medicine > Journal Articles
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