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Infection Route Impacts the Pathogenesis of Severe Fever with Thrombocytopenia Syndrome Virus in Ferretsopen access

Authors
Park, Su-JinKim, Young-IlCasel, Mark AnthonyKim, Eun-HaKim, Se-MiYu, Kwang-MinRollon, RareJang, Seung-GyuJeong, Hye WonChoi, Young Ki
Issue Date
Jun-2022
Publisher
MDPI
Keywords
SFTSV; animal model; aged ferret; infection routes
Citation
VIRUSES-BASEL, v.14, no.6
Indexed
SCIE
SCOPUS
Journal Title
VIRUSES-BASEL
Volume
14
Number
6
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/1214
DOI
10.3390/v14061184
ISSN
1999-4915
Abstract
The threat of severe fever with thrombocytopenia syndrome (SFTS) to public health has been increasing due to the rapid spread of the ticks that carry the causative viral agent. The SFTS virus (SFTSV) was first identified in China and subsequently detected in neighboring countries, including South Korea, Japan, and Vietnam. In addition to the tick-mediated infection, human-to-human transmission has been recently reported with a high mortality rate; however, differential study of the pathogen has been limited by the route of infection. In this study, we investigated the pathogenic potential of SFTSV based on the infection route in aged ferrets, which show clinical signs similar to that of human infections. Ferrets inoculated with SFTSV via the intramuscular and subcutaneous routes show clinical signs comparable to those of severe human infections, with a mortality rate of 100%. Contrastingly, intravascularly infected ferrets exhibit a comparatively lower mortality rate of 25%, although their early clinical signs are similar to those observed following infection via the other routes. These results indicate that the infection route could influence the onset of SFTS symptoms and the pathogenicity of SFTSV. Thus, infection route should be considered in future studies on the pathogenesis of SFTSV infection.
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자연과학대학 (생명과학부)
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