Detailed Information

Cited 26 time in webofscience Cited 23 time in scopus
Metadata Downloads

Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study

Authors
Roh, EunHwang, Soon YoungYoo, Hye JinBaik, Sei HyunLee, Jin-HeeSon, Sang JoonKim, Hyeon JuPark, Yong SoonLee, Sam-GyuCho, Be LongJang, Hak ChulKim, Bong JoKim, MijiWon, Chang WonChoi, Kyung Mook
Issue Date
Jun-2022
Publisher
SPRINGER
Keywords
Muscle; Skeletal; Muscle strength; Sarcopenia; Nonalcoholic fatty liver disease; Cohort
Citation
HEPATOLOGY INTERNATIONAL, v.16, no.3, pp 545 - 554
Pages
10
Indexed
SCIE
SCOPUS
Journal Title
HEPATOLOGY INTERNATIONAL
Volume
16
Number
3
Start Page
545
End Page
554
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/1192
DOI
10.1007/s12072-021-10258-8
ISSN
1936-0533
1936-0541
Abstract
Background and aims Despite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study. Methods A total of 1595 community-dwelling people aged 70-84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study. Muscle mass was estimated by dividing appendicular skeletal muscle mass (ASM) by body mass index (BMI). Muscle strength was measured as handgrip strength (HGS) divided by BMI. The sex-specific lowest quintiles of ASM/BMI and HGS/BMI of the study population were used as cutoffs for LMM and LMS, respectively. The risk of LMM and LMS were assessed according to hepatic steatosis index (HSI) and fatty liver index (FLI) quartiles. Results As HSI quartiles increased, the LMM risk increased gradually, after adjusting for age, sex, lifestyle factors, comorbidities, and several causative factors (insulin resistance, inflammation, and vitamin D) (Q4 vs. Q1 OR [95% CI] 3.46 [2.23-5.35]). The increased risk of LMS was even higher according to HSI quartiles (Q4 vs. Q1 5.81 [3.67-9.21]). Multivariate analyses based on FLI showed similar results. People with NAFLD (HSI> 36) were at higher risk of developing LMM and LMS compared to those without (1.65 [1.19-2.31] and 2.29 [1.61-3.26], respectively). Conclusions The presence of NAFLD may predict future risk of LMM and LMS, with greater impact on LMS than on LMM. [GRAPHICS] .
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Bong Cho photo

Kim, Bong Cho
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE