Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model
DC Field | Value | Language |
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dc.contributor.author | Park, Dong-Ju | - |
dc.contributor.author | Shah, Fawad-Ali | - |
dc.contributor.author | Koh, Phil-Ok | - |
dc.date.accessioned | 2022-12-26T17:04:06Z | - |
dc.date.available | 2022-12-26T17:04:06Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 0916-7250 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/11774 | - |
dc.description.abstract | Cerebral ischemia is a neurological disorder with high mortality. Quercetin is a flavonoid compound that is abundant in vegetables and fruits. It exerts anti-inflammatory and anti-apoptotic effects. This study investigated the neuroprotective effects of quercetin in focal cerebral ischemia. Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) to induce focal cerebral ischemia. Quercetin or vehicle was injected 30 min before the onset of ischemia. A neurological function test, brain edema measurement, and 2,3,5-triphenyltetrazolium chloride staining were performed to elucidate the neuroprotective effects of quercetin. Western blot analysis was performed to observe caspase-3 and poly ADP-ribose polymerase (PARP) protein expression. MCAO leads to severe neuronal deficits and increases brain edema and infarct volume. However, quercetin administration attenuated the MCAO-induced neuronal deficits and neuronal degeneration. We observed increases in caspase-3 and PARP protein levels in MCAO-operated animals injected with vehicle, whereas quercetin administration attenuated these increases in MCAO injury. This study reveals the neuroprotective effect of quercetin in an MCAO-induced animal model and demonstrates the regulation of caspase-3 and PARP expression by quercetin treatment. These results suggest that quercetin exerts a neuroprotective effect through preventing the MCAO-induced activation of apoptotic pathways affecting caspase-3 and PARP expression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | JAPAN SOC VET SCI | - |
dc.subject | SPONTANEOUSLY HYPERTENSIVE-RATS | - |
dc.subject | FLAVONOID QUERCETIN | - |
dc.subject | BLOOD-PRESSURE | - |
dc.subject | ISCHEMIA | - |
dc.subject | BRAIN | - |
dc.subject | REPERFUSION | - |
dc.subject | MECHANISMS | - |
dc.subject | INJURY | - |
dc.subject | EXPRESSION | - |
dc.subject | PATHWAY | - |
dc.title | Quercetin attenuates neuronal cells damage in a middle cerebral artery occlusion animal model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Phil-Ok | - |
dc.identifier.doi | 10.1292/jvms.17-0693 | - |
dc.identifier.scopusid | 2-s2.0-85046156462 | - |
dc.identifier.wosid | 000431565300022 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VETERINARY MEDICAL SCIENCE, v.80, no.4, pp.676 - 683 | - |
dc.relation.isPartOf | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.citation.title | JOURNAL OF VETERINARY MEDICAL SCIENCE | - |
dc.citation.volume | 80 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 676 | - |
dc.citation.endPage | 683 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | SPONTANEOUSLY HYPERTENSIVE-RATS | - |
dc.subject.keywordPlus | FLAVONOID QUERCETIN | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | REPERFUSION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | caspase-3 | - |
dc.subject.keywordAuthor | neuroprotection | - |
dc.subject.keywordAuthor | PARP | - |
dc.subject.keywordAuthor | quercetin | - |
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