Ovataline: A Polyketide Isolated from the Benthic Dinoflagellate Ostreopsis cf. ovata with 5 alpha-Reductase Inhibitory Activity in RWPE-1 Prostatic Cells
- Lee, Sangbum; Moon, Seung Joo; Du Yoo, Yeong; Hwang, Byung Su; Jeong, Eun Ju; Rho, Jung-Rae
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- AMER CHEMICAL SOC
- ORGANIC LETTERS, v.24, no.23, pp.4182 - 4186
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- ORGANIC LETTERS
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- Ovataline (1), which is a polar metabolite containing a hexahydroquinoline moiety, was isolated from cultures of the marine dinoflagellate Ostreopsis cf. ovata. 1 was characterized as a zwitterionic compound with hexahydroquinoline and tetrahydropyran rings. The configurations of the chiral centers in 1 were established using ROESY correlations, Piased configurational and Mosher reaction analyses, and density functional theory calculations. 1 exhibited a 78% (1 mu M) inhibition of type II 5 alpha-reductase in testosterone propionate-induced RWPE-1 human prostatic cells.
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- 자연과학대학 > 항노화신소재과학과 > Journal Articles
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