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Cited 27 time in webofscience Cited 33 time in scopus
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Chokeberry Extract and Its Active Polyphenols Suppress Adipogenesis in 3T3-L1 Adipocytes and Modulates Fat Accumulation and Insulin Resistance in Diet-Induced Obese Miceopen access

Authors
Kim, Na-HyunJegal, JonghwanKim, Yun NaHeo, Jeong-DooRho, Jung-RaeYang, Min HyeJeong, Eun Ju
Issue Date
Nov-2018
Publisher
MDPI
Keywords
Aronia melanocarpa; polyphenols; anti-adipogenesis; adipogenic transcription factor; diet-induced obesity; insulin resistance
Citation
NUTRIENTS, v.10, no.11
Indexed
SCIE
SCOPUS
Journal Title
NUTRIENTS
Volume
10
Number
11
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/11086
DOI
10.3390/nu10111734
ISSN
2072-6643
Abstract
Berries of Aronia melanocarpa (chokeberry) are known to be a rich source of biologically active polyphenols. In the present study, the effects of seven anti-adipogenic polyphenolic phytochemicals isolated from A. melanocarpa methanol extract on adipogenic transcription factors were investigated. Amygdalin and prunasin were found to inhibit 3T3-L1 adipocyte differentiation by suppressing the expressions of PPAR gamma (peroxisome proliferator-activated receptor gamma), C/EBP alpha(CCAAT/enhancer binding protein alpha), SREBP1c (sterol regulatory element binding protein 1c), FAS (fatty acid synthase), and aP2 (adipocyte fatty-acid-binding protein). A. melanocarpa extract-treated (100 or 200 mg/kg/day on body weight) high fat diet (HFD)-induced obese mice showed significant decreases in body weight, serum triglyceride (TG), and low-density lipoprotein cholesterol (LDLC) levels and improved insulin sensitivity as compared with HFD controls. This research shows A. melanocarpa extract is potentially beneficial for the suppression of HFD-induced obesity.
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자연과학대학 (항노화신소재과학과)
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