ScholarWorks@경상국립대학교

초록

Treatment with eculizumab increases the risk of invasive meningococcal infection (IMI). We evaluated tetravalent meningococcal vaccine responses in pediatric hematopoietic cell transplant (HCT) recipients with eculizumab for veno-occlusive disease (eculizumab group, n=4) and compared to patients with asplenia/polysplenia (asplenia/ polysplenia group, n=2). Among the eculizumab group, two patients had a partial and full antibody response, respectively; two had no response. In contrast, the asplenia/polysplenia group showed full responses. These findings suggest poor vaccine response in HCT patients receiving eculizumab during the early post-HCT period, indicating limited meningococcal vaccine response and a need for antibiotic prophylaxis to prevent IMI in this group.

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