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A bisdesmosidic cholestane glycoside from the rhizomes of Polygonatum sibiricum
- Ahn, M.-J.;
- Cho, H.;
- Lee, M.K.;
- Bae, J.Y.;
- Choi, J.;
- 외 2명
Citations
SCOPUS
9초록
A bisdesmosidic cholestane glycoside was isolated from the rhizomes of Polygonatum sibiricum and the structure was elucidated by spectroscopic methods and acid hydrolysis as (22S)-cholest-5-ene-1β,3β,16β,22- tetrol 1-O-α-L-rhamnopyranosyl 16-O-β-D-glucopyranoside. This compound exhibited weak cytotoxic activity with the IC 50 value, 63.6 μM in human MCF-7 breast cancer line, whereas it failed to show agonistic activity at 100 μM in TGR5 assay with Chinese hamster ovary (CHO) cells. This is the first report of a bisdesmosidic cholestane glycoside from Polygonatum species and the full assignments of 1H, 13C NMR by HMBC, TOCSY and NOESY experiments were provided.
키워드
Cholestane glycoside; Cytotoxic activity; Polygonatum sibiricum; Spectroscopic methods
- 제목
- A bisdesmosidic cholestane glycoside from the rhizomes of Polygonatum sibiricum
- 저자
- Ahn, M.-J.; Cho, H.; Lee, M.K.; Bae, J.Y.; Choi, J.; Kim, C.Y.; Kim, J.
- 발행일
- 2011
- 유형
- Article
- 권
- 17
- 호
- 3
- 페이지
- 183 ~ 188
- 언어
- ENG
- 발행국가
- 대한민국
- 분량
- 6 페이지
- ISSN
- P 1226-3907