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- Amatya, Reeju;
- Joseph, Amala;
- Roh, Gu Seob;
- Cho, Kwan Hyung;
- Moon, Cheol;
- ... Shin, Meong Cheol;
- 외 1명
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PurposeA long-acting exendin-4 (EX-ABD-AFF)-coated selenium nanoparticle (EX-ABD-AFF-SeNP) was synthesized, and its hypoglycemic activity was evaluated in vivo.MethodsEX-ABD-AFF-SeNP was prepared by adopting a one-step aqueous reduction process. Its physical characteristics, stability, cytotoxicity, pharmacokinetics (PK), biodistribution, and preliminary efficacy were evaluated.ResultsThe successful synthesis of EX-ABD-AFF-SeNP was confirmed through transmission electron microscopy, dynamic light scattering, ultraviolet-visible light spectroscopy, and Fourier transform infrared spectroscopy. The prepared EX-ABD-AFF-SeNP showed low cytotoxicity in different cell lines. Notably, the EX-ABD-AFF-SeNP showed long-lasting features in blood circulation with subcutaneous (s.c.) administration. The group treated with the EX-ABD-AFF-SeNP exhibited significant and superior hypoglycemic activity compared to the other groups. This hypoglycemic activity was demonstrated through measurements in high-fat diet mice, indicating its potential as an effective diabetes treatment.ConclusionThe study's findings demonstrated that EX-ABD-AFF-SeNP might be an efficient therapeutic agent for diabetes treatment, potentially inspiring new avenues for diabetes research and treatment.
키워드
- 제목
- Long-acting exendin-4-coated selenium nanoparticles with improved hypoglycemic activity
- 저자
- Amatya, Reeju; Joseph, Amala; Roh, Gu Seob; Cho, Kwan Hyung; Moon, Cheol; Min, Kyoung Ah; Shin, Meong Cheol
- 발행일
- 2025-09
- 유형
- Article
- 권
- 55
- 호
- 5
- 페이지
- 761 ~ 769