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A new pancreatic lipase inhibitor from Broussonetia kanzinoki
- Ahn, Jong Hoon;
- Liu, Qing;
- Lee, Chul;
- Ahn, Mi-Jeong;
- Yoo, Hwan-Soo;
- 외 2명
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46초록
A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4 '-dihydroxyflavan (4), 3 ',7-dihydroxy-4 '-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4 '-methoxyflavone (6), 3,7,3 '-trihydroxy-4 '-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC50 of 28.4 mu M. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay. (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Broussonetia kanzinoki; Moraceae; Pancreatic lipase; Broussonone Lambda; Adipocyte differentiation; ORLISTAT; OBESITY
- 제목
- A new pancreatic lipase inhibitor from Broussonetia kanzinoki
- 저자
- Ahn, Jong Hoon; Liu, Qing; Lee, Chul; Ahn, Mi-Jeong; Yoo, Hwan-Soo; Hwang, Bang Yeon; Lee, Mi Kyeong
- 발행일
- 2012-04-15
- 유형
- Article
- 권
- 22
- 호
- 8
- 페이지
- 2760 ~ 2763
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 1464-3405
P 0960-894X