Effects of honey from Hedera rhombea Bean on dyslipidemia and oxidative stress in high-fat diet-induced mice

초록

This study investigated the effects of honey from Hedera rhombea Bean (HRH) on dyslipidemia and oxidative stress in high-fat diet-induced mice and tumor necrosis factor (TNF)-alpha-stimulated human umbilical vein endothelial cells. HRH administration (0.5 and 1 g/kg/day for 4 weeks) significantly improved serum lipid profiles by decreasing total cholesterol, low-density lipoprotein cholesterol, and the atherogenic index. HRH-administered mice showed significantly reduced serum thromboxane B2 and coagulation factor VII levels, suggesting improved biomarkers associated with platelet activation and coagulation. Moreover, HRH attenuated hepatic oxidative stress by decreasing lipid peroxidation, nitric oxide, and reactive oxygen species (ROS) levels and upregulating antioxidant-related genes and antioxidant enzymes and increasing p-AMPK. Furthermore, HRH treatment significantly reduced TNF-alpha-induced intracellular ROS production dose-dependently. Therefore, HRH may be a potential functional food ingredient for improving dyslipidemia and oxidative stress by regulating lipid metabolism, antioxidant defense systems, and AMPK signaling.

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