상세 보기
One-Pot Synthesis of Unprotected 2-Acylpyrroles from 1,2,3 -Triazoles and 2-Hydroxymethylallyl Carbonates
- Park, J.-U.;
- Huang, L.-Z.;
- Cho, H.-J.;
- Park, B.Y.;
- Kim, J.H.
Citations
WEB OF SCIENCE
5Citations
SCOPUS
6초록
An efficient, tandem one-pot approach to synthesize multisubstituted 2-acylpyrroles from readily prepared N-tosyl triazoles and 2-hydroxymethylallyl carbonates is reported. The reaction proceeds via Rh(II)-catalyzed O-H insertion, [3,3]-sigmatropic rearrangement, Pd(0)-catalyzed oxidative addition, intramolecular cyclization, DBU-promoted E1cB elimination, double bond isomerization, and aromatization, enabling the disconnection and formation of multiple bonds in one reactor. The approach represents a highly regioselective way to access di-, tri-, and tetra-substituted NH pyrroles with high efficiency. © 2022 American Chemical Society.
키워드
HIGHLY SUBSTITUTED PYRROLES; POLYSUBSTITUTED PYRROLES; REGIOSELECTIVE SYNTHESIS; TERMINAL ALKYNES; STEP ECONOMY; THERMAL REARRANGEMENT; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; ATOM ECONOMY; COPPER
- 제목
- One-Pot Synthesis of Unprotected 2-Acylpyrroles from 1,2,3 -Triazoles and 2-Hydroxymethylallyl Carbonates
- 저자
- Park, J.-U.; Huang, L.-Z.; Cho, H.-J.; Park, B.Y.; Kim, J.H.
- 발행일
- 2023-01
- 유형
- Article
- 권
- 88
- 호
- 1
- 페이지
- 585 ~ 593