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초록
A nanoplasmonic biosensor for the precise detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by leveraging advances in nanostructured sensing materials and highly selective monoclonal antibodies is presented. The sensor integrates plasmonic Au nanostructures optimized for surface-enhanced Raman scattering (SERS), enhancing sensitivity through unique light interactions at the nanoscale. Coupled with exclusive antibodies that specifically target SARS-CoV-2 and its evolving variants, this sensor demonstrates remarkable selectivity and versatility. Validated with 270 clinical samples, it demonstrates a sensitivity of 98.9% and specificity of 100%. More importantly, the virus in nasopharyngeal swab samples collected over 3 years, marking the long-term, large-scale clinical validation of the nanoplasmonic biosensor for SARS-CoV-2 is been successfully detected. Furthermore, the integration of this sensor with face masks enables the detection of airborne SARS-CoV-2, highlighting its potential for routine management of coronavirus disease 2019 (COVID-19). © 2024 The Author(s). Advanced Functional Materials published by Wiley-VCH GmbH.
키워드
- 제목
- Advancing SARS-CoV-2 Variant Detection with High Affinity Monoclonal Antibodies and Plasmonic Nanostructure
- 저자
- Ryu, Jea Sung; Lee, Soo Hyun; Kim, Hyeran; Kang, Hyunju; Li, Pei; Lee, Joo Hoon; Jang, Hyowon; Kim, Sunjoo; Kwon, Hyung-Jun; Jung, Ho Sang; Jung, Yongwon; Lim, Eun-Kyung; Jung, Juyeon; Park, Sung-Gyu; Kang, Taejoon
- 발행일
- 2024-11
- 유형
- Article
- 권
- 34
- 호
- 45