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초록
Regioselective approaches toward 2H- and 3H-pyrroles,which are biologically important but easily isomerizable compounds, have been successfully achieved via dual Rh(II)/Pd(0) relay catalysis and DBU-mediated processes in one-pot operation using N-tosyltriazoles and hydroxymethylallyl carbonates. In this transformation, readily accessible N-tosyltriazoles were enabled as stable nitrogen sources for the two scaffolds, and the regioselectivity was controlled by the substituent positions of the hydroxymethylallyl carbonates.
키워드
2H -pyrrole; 3H -pyrrole; dual catalysis; regioselectivity; N -tosyltriazole; ASYMMETRIC ALLYLIC DEAROMATIZATION; ENANTIOSELECTIVE SYNTHESIS; FUNCTIONALIZATION; HETEROCYCLES; CASCADE; ESTERS; SPIRO
- 제목
- Tandem One-Pot Synthesis of 2 <i>H</i> - and 3 <i>H</i> -Pyrroles Enabled by Dual Rh(II)/Pd(0) Catalysis
- 저자
- Choi, Seoung-Mi; Yun, Yuri; Kim, Ju Hyun
- 발행일
- 2024-11
- 유형
- Article
- 저널명
- Synthesis
- 권
- 56
- 호
- 22
- 페이지
- 3405 ~ 3411