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초록
Mesenchymal-to-epithelial transition factor (c-MET) is a receptor for hepatocyte growth factor (HGF) found in epithelial tissues. It plays a crucial role in cell survival, growth, differentiation, and angiogenesis. In particular, c-MET activation is closely associated with cancer cell migration, invasion, and metastasis, while aberrant HGF/ c-MET signaling promotes the progression of various cancers. Based on these findings, various drugs targeting the HGF/c-MET signaling pathway have been developed. This review summarizes the preclinical and clinical evaluations of antibody-based inhibitors, three types of small-molecule c-MET tyrosine kinase inhibitors, and radiopharmaceuticals derived from these drug structures, emphasizing recent advancements in c-MET inhibitors.
키워드
- 제목
- Recent Advances in c-MET Inhibitors and c-MET Target Radiopharmaceuticals: Novel Approaches for Cancer Diagnostics
- 저자
- Dagyeong Hong; 김동연; 표아영
- 발행일
- 2024-12
- 저널명
- Journal of Radiopharmaceuticals and Molecular Probes
- 권
- 10
- 호
- 2
- 페이지
- 171 ~ 180