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Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors
- Ryu, Jae Wook;
- Han, Sun-Young;
- Yun, Jeong In;
- Choi, Sang-Un;
- Jung, Heejung;
- 외 7명
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18초록
A series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T). (C) 2011 Elsevier Ltd. All rights reserved.
키워드
c-Met; Cancer; Kinase inhibitor; Triazolopyridazine; Methylisoquinolinone; CANCER; DISCOVERY; AMPLIFICATION; SENSITIVITY; ONCOGENE; RECEPTOR
- 제목
- Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors
- 저자
- Ryu, Jae Wook; Han, Sun-Young; Yun, Jeong In; Choi, Sang-Un; Jung, Heejung; Du Ha, Jae; Cho, Sung Yun; Lee, Chong Ock; Kang, Nam Sook; Koh, Jong Sung; Kim, Hyoung Rae; Lee, Jongkook
- 발행일
- 2011-12
- 유형
- Article
- 권
- 21
- 호
- 23
- 페이지
- 7185 ~ 7188