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Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae
- Ahn, M.-J.;
- Yoon, K.-D.;
- Kim, C.Y.;
- Kim, J.H.;
- Shin, C.-G.;
- 외 1명
Citations
SCOPUS
59초록
The bioassay-directed isolation of a marine brown alga, Ishige okamurae, afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV-1 reverse transcriptase and integrase with IC50 values of 9.1 μM, and 25.2 μM, respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HTV-1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes. Copyright ? 2006 John Wiley & Sons, Ltd.
키워드
Diphlorethohydroxycarmalol; Diphlorethohydroxycarmalol nonaacetate; HIV-1 reverse transcriptase; Integrase; Ishige okamurae; Protease
- 제목
- Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae
- 저자
- Ahn, M.-J.; Yoon, K.-D.; Kim, C.Y.; Kim, J.H.; Shin, C.-G.; Kim, J.
- DOI
- 10.1002/ptr.1939
- 발행일
- 2006
- 유형
- Article
- 권
- 20
- 호
- 8
- 페이지
- 711 ~ 713
- 언어
- ENG
- 발행국가
- 미국
- 분량
- 3 페이지
- ISSN
- E 1099-1573
P 0951-418X