만성 알코올 섭취로부터 유도되는 뇌 및 간 조직 독성에 대한 지구자 혼합추출물의 보호 효과

초록

To assess the industrial possibility of mixed-extracts containing Hovenia dulcis Thunberg and12 different botanical ingredients, a protective effect was confirmed in the chronicethanol-induced the liver, brain, and blood injury in mouse. Blood glucose levels of the normalcontrol group(NG) and ethanol administration group(EG) were respectively 119.43mg/dL and305.25mg/dL, and the mixed-extracts administration group(100, 200mg/kg body weight + 25%ethanol 5g/kg body weight respectively; ME100 & ME200) were decreased to 272.76mg/dL and 234.60mg/dL. Blood ethanol contents were decreased in ME100 and ME200(3.85mg/dL,3.08mg/dL) compared to EG(4.08mg/dL), and blood acetaldehyde contents were also decreasedin ME(15.76mg/dL, 15.16mg/dL) compared to EG(18.72mg/dL). The contents of hepatotoxicindicators such as glutamine pyruvic transaminase(GPT) and glutamic oxaloacetic transaminase(GOT), nephrotoxic indicators such as blood urea nitrogen(BUN), and creatine(CRE), and totalcholestero(TCHO), and triglyceride(TG) in mouse blood serum were significantly decreased inthe ME compared to EG. The acetylcholinesterase(AChE) activity of ME(109.00% and 108.47%,respectively) in mouse brain tissues was decreased in ME compared to EG(116.10%). Finally,ME was remarkable in vivo antioxidant activities in the mouse liver and brain tissues bysuperoxide dismutase(SOD), oxidized glutathione(GSH)/total GSH ratio and the malondialdehyde(MDA) assay. Therefore, the mixed-extracts was considered to be effective a high value foodwith protective effect against chronic ethanol traetment-induced cytotoxicity in liver and braintissues.

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