Differences of Key Proteins between Apoptosis and Necroptosis
  • Park, Min Yeong
  • Ha, Sang Eun
  • Vetrivel, Preethi
  • Kim, Hun Hwan
  • Bhosale, Pritam Bhangwan
  • ... Kim, Gon Sup
  • 외 1명
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초록

Many different types of programmed cell death (PCD) have been identified, including apoptosis and necroptosis. Apoptosis is a type of cell death that is controlled by various genes. It is in charge of eliminating aberrant cells such as cancer cells, replenishing normal cells, and molding the body as it develops. Necroptosis is a type of programmed cell death that combines necrosis and apoptosis. In other words, it takes on a necrotic appearance, although cells die in a controlled manner. Various investigations of these two pathways have revealed that caspase-8, receptor-interacting serine/threonine-protein kinase 1 (RIPK1), and RIPK3 are crucial proteins in charge of the switching between these two pathways, resulting in the activation or inhibition of necroptosis. In this review, we have summarized the key proteins between apoptosis and necroptosis.

키워드

PROGRAMMED CELL-DEATHCANCERCASPASE-8RIPK1MECHANISMSPATHWAYS
제목
Differences of Key Proteins between Apoptosis and Necroptosis
저자
Park, Min YeongHa, Sang EunVetrivel, PreethiKim, Hun HwanBhosale, Pritam BhangwanAbusaliya, AbuyaseerKim, Gon Sup
DOI
10.1155/2021/3420168
발행일
2021-12
유형
Review
저널명
BioMed Research International
2021