RAB27A is an independent prognostic factor in clear cell renal cell carcinoma

An, Hyo Jung; Song, Dae Hyun; Koh, Hyun Min; Ko, Gyung Hyuck; Lee, Jeong-Hee; Kim, Dong Chul; Yang, Jung Wook; Kim, Min Hye; Seo, Deok Ha; Jang, Se Min; Lee, Jong Sil

doi:10.2217/bmm-2018-0336

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RAB27A is an independent prognostic factor in clear cell renal cell carcinoma

An, Hyo Jung;
Song, Dae Hyun;
Koh, Hyun Min;
Ko, Gyung Hyuck;
Lee, Jeong-Hee;
... Kim, Dong Chul;
... Lee, Jong Sil;
외 4명

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초록

Aim: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). Materials & methods: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. Results: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128-41.241; p-value = 0.036). Conclusion: RAB27A is an independent prognostic factor in CCRCC.

키워드

clear cell; intensity; metastasis; nuclear grade; progression; RAB27A; RAB27B; renal cell carcinoma; T stage; tumor; GTPASES

제목: RAB27A is an independent prognostic factor in clear cell renal cell carcinoma

저자: An, Hyo Jung; Song, Dae Hyun; Koh, Hyun Min; Ko, Gyung Hyuck; Lee, Jeong-Hee; Kim, Dong Chul; Yang, Jung Wook; Kim, Min Hye; Seo, Deok Ha; Jang, Se Min; Lee, Jong Sil

DOI: 10.2217/bmm-2018-0336

발행일: 2019-03

유형: Article

저널명: Biomarkers in Medicine

권: 13

호: 4

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