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RAB27A is an independent prognostic factor in clear cell renal cell carcinoma
- An, Hyo Jung;
- Song, Dae Hyun;
- Koh, Hyun Min;
- Ko, Gyung Hyuck;
- Lee, Jeong-Hee;
- ... Kim, Dong Chul;
- ... Lee, Jong Sil;
- 외 4명
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14초록
Aim: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). Materials & methods: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. Results: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128-41.241; p-value = 0.036). Conclusion: RAB27A is an independent prognostic factor in CCRCC.
키워드
clear cell; intensity; metastasis; nuclear grade; progression; RAB27A; RAB27B; renal cell carcinoma; T stage; tumor; GTPASES
- 제목
- RAB27A is an independent prognostic factor in clear cell renal cell carcinoma
- 저자
- An, Hyo Jung; Song, Dae Hyun; Koh, Hyun Min; Ko, Gyung Hyuck; Lee, Jeong-Hee; Kim, Dong Chul; Yang, Jung Wook; Kim, Min Hye; Seo, Deok Ha; Jang, Se Min; Lee, Jong Sil
- 발행일
- 2019-03
- 유형
- Article
- 권
- 13
- 호
- 4
- 페이지
- 239 ~ 247
- 언어
- ENG
- 출판사
- FUTURE MEDICINE LTD
- 발행국가
- 영국
- 분량
- 9 페이지
- ISSN
- E 1752-0371
P 1752-0363