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Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
- Heo, Yu Mi;
- Lee, Hunseok;
- Shin, Young Kee;
- Paek, Seung-Mann
Citations
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3초록
The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative.
키워드
macrosphelides; natural product; total synthesis; THIAZOLE SIDE-CHAIN; CELL-CELL ADHESION; NATURAL-PRODUCTS; ARTIFICIAL MACROSPHELIDES; DRUG DISCOVERY; SEA HARE; APOPTOSIS; (+)-MACROSPHELIDE-B; INHIBITORS; LIBRARY
- 제목
- Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivative
- 저자
- Heo, Yu Mi; Lee, Hunseok; Shin, Young Kee; Paek, Seung-Mann
- 발행일
- 2014-10
- 유형
- Article
- 저널명
- Molecules
- 권
- 19
- 호
- 10
- 페이지
- 15572 ~ 15583
- 언어
- ENG
- 출판사
- MDPI
- 발행국가
- 스위스
- 분량
- 12 페이지
- ISSN
- P 1420-3049