상세 보기
- Kang, Heeyoung;
- Shin, Hyun Joo;
- An, Hyeong Seok;
- Jin, Zhen;
- Lee, Jong Youl;
- ... Jeong, Eun Ae;
- ... Roh, Gu Seob;
- 외 7명
WEB OF SCIENCE
26SCOPUS
25초록
Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer's disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (A beta O) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood-brain barrier disruption in A beta O-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress.
키워드
- 제목
- Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer's Disease
- 저자
- Kang, Heeyoung; Shin, Hyun Joo; An, Hyeong Seok; Jin, Zhen; Lee, Jong Youl; Lee, Jaewoong; Kim, Kyung Eun; Jeong, Eun Ae; Choi, Kyu Yeong; McLean, Catriona; Lee, Kun Ho; Kim, Soo Kyoung; Lee, Hae Ryong; Roh, Gu Seob
- 발행일
- 2021-11
- 유형
- Article
- 저널명
- Antioxidants
- 권
- 10
- 호
- 11