Long-Term Tolerability of Escitalopram in Korean Adolescents

초록

Objectives：We investigated the long-term tolerability of escitalopram in Korean adolescents. Methods：The subjects were 37 adolescents, who had been diagnosed with depressive disorder in accordance to DSM-IV. Clinical effectiveness was assessed by Clinical Global Impression-Improvement (CGI-I) scale at the final follow-up visit. Tolerabilitywas assessed through a medical record of the reason for discontinuation of escitalopram and documented adverse events. Results：The mean duration of treatment was 78.1±89.5 days, and the mean dosage was 10.0±4.4mg/day. Out of the total 37patients, two (5%) patients sustained use of escitalopram. Twelve patients (32.4%) discontinued use of escitalopram due to targetsymptom remission, and 23 patients (61.9%) due to insufficient efficacy. Six patients (16.2%) had at least one documented adverseevent. However, no suicidal ideation or self-injurious behavior was reported. Significant differences in clinical symptom improvementefficacy were seen between the patients who were receiving escitalopram for less than 8 weeks (4.3%, 1/13) and those formore than 8 weeks (92.9%, 13/14). There was no significant difference between the tolerability of monotherapy compared to theconcomitant use group. Conclusion：The results of this study suggest that long-term use of escitalopram may result in superior efficacy than shorttermuse, and is tolerable in Korean adolescents with depression.

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