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Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
- Yu, E.-A.;
- Cha, C.-N.;
- Park, E.-K.;
- Yoo, C.-Y.;
- Kim, S.;
- 외 1명
Citations
SCOPUS
0초록
This study evaluated the antibacterial effects of a mixture of Sophorae radix and Glycyrrhiza uralensis Fischer (1: 1) ethanol extracts (SGE) on mice infected with Streptococcus (S.) pyogenes. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration of SGE necessary for antibacterial effects against S. pyogenes were 20 μg/mL. Based on the time-kill curves for S. pyogenes, SGE was effective at 4× MIC after 16 h. On Day 12 after challenge, the survival rate of mice treated with 2.0 mg/kg SGE was 60%. In conclusion, SGE had potent in vitro and in vivo antibacterial activities against S. pyogenes.
키워드
Crude extracts; Medicinal plants; Mice; Streptococcus pyogenes; Treatment efficacy
- 제목
- Antibacterial and therapeutic effects of a combination of Sophora flavescens and Glycyrrhiza uralensis Fischer ethanol extracts on mice infected with Streptococcus pyogenes
- 저자
- Yu, E.-A.; Cha, C.-N.; Park, E.-K.; Yoo, C.-Y.; Kim, S.; Lee, H.-J.
- 발행일
- 2014
- 유형
- Article
- 저널명
- 대한수의학회지
- 권
- 54
- 호
- 3
- 페이지
- 189 ~ 192
- 언어
- ENG
- 출판사
- Korean Society of Veterinary Science
- 발행국가
- 대한민국
- 분량
- 4 페이지
- ISSN
- E 2466-1392
P 2466-1384