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초록
This study evaluated the association of atherogenic index of plasma (AIP) with platelet reactivity and clinical outcomes according to acute myocardial infarction (AMI). The composite of 3-year adverse outcomes of all-cause death, myocardial infarction, and cerebrovascular accident was evaluated in 10,735 patients after successful percutaneous coronary intervention with drug-eluting stents. AIP was defined as the base 10 logarithm of the ratio of triglyceride to high-density lipoprotein cholesterol concentration. High platelet reactivity (HPR) was defined as ≥ 252 P2Y12 reactivity unit. An increase of AIP (per-0.1 unit) was related to the decreased risk of HPR [odds ratio (OR) 0.97, 95% confidence interval (CI) 0.96–0.99; P = 0.001] in non-AMI patients, not in AMI patients (OR 0.98, 95% CI 0.96–1.01; P = 0.138). The HPR was associated with the increased risk of composite outcomes in both non-AMI and AMI patients (all-P < 0.05). AIP levels were not independently associated with the risk of composite outcomes in both patients with non-AMI and AMI. In conclusion, an inverse association between AIP and the risk of HPR was observed in patients with non-AMI. This suggests that the association between plasma atherogenicity and platelet reactivity may play a substantial role in the development of AMI. Trial registration: NCT04734028. © The Author(s) 2024.
키워드
- 제목
- Different association of atherogenic index of plasma with the risk of high platelet reactivity according to the presentation of acute myocardial infarction
- 저자
- Won, Ki-Bum; Kim, Hyeon Jeong; Cho, Jun Hwan; Lee, Sang Yup; Her, Ae-Young; Kim, Byeong-Keuk; Joo, Hyung Joon; Park, Yongwhi; Chang, Kiyuk; Song, Young Bin; Ahn, Sung Gyun; Suh, Jung-Won; Cho, Jung Rae; Kim, Hyo-Soo; Kim, Moo Hyun; Lim, Do-Sun; Kim, Sang-Wook; Jeong, Young-Hoon; Shin, Eun-Seok
- 발행일
- 2024-05
- 유형
- Article
- 권
- 14
- 호
- 1